Home
Disorder
Domains
Protein interactions
Sub-complexes    CPSF
   CstF
   CFIm
   CFIIm
Other proteins    PABP-1
   PAP
   RPB1
   PP-1A
   PP-1B
   Symplekin
   WDR82
   SSU72
   RBBP6
Download
FAQ

Human pre-mRNA 3'-end processing machinery database


CF IIm - mammalian cleavage factor II



         It is build from two proteins which are conserved from yeast to human. The exact function is unknown. CFIIm in human is required for the cleavage step, while in Drosophila and yeast it is required both for pre-mRNA 3' processing and translational termination. Pcf11 binds to C terminal part of RPB1 protein (this interacion depends on phosphorylation of CTD). Although, Clp1 can acts as an RNA 5'-kinase it is not clear if this activity is necessary for pre-mRNA 3' processing.

Literature:


Contact: Lukasz Kozlowski
This work was supported by Polish Ministry of Science and Higher Education (grant NN301 190139).

Valid HTML 4.01!