Home
Disorder
Domains
Protein interactions
Sub-complexes    CPSF
   CstF
   CFIm
   CFIIm
Other proteins    PABP-1
   PAPOLA
   RPB1
   PP-1A
   PP-1B
   Symplekin
   WDR82
   SSU72
   RBBP6
Download
FAQ

Serine/threonine-protein phosphatase PP1-beta catalytic subunit


Known abbreviations: PP-1B, PP1B, PP1beta, PPP1CB, PPP1CD

Yeast homolog: GLC7

Protein




Models
Domains

Secondary structure

Disorder

Top 3 models:
Template: 1s70, chain A
Method: ffas
Fragment: 1-326
Template: 1s70, chain A
Method: compass
Fragment: 2-306
Template: 1fjm, chain A
Method: hhsearch
Fragment: 1-325


Sequence length:327 aa
Molecular weight:37.187 kDa
Isoelectric point:5.91

Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASIN
RIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKR
QLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR


Enzyme
EC number: 3.1.3.16
Name: Phosphoprotein phosphatase
Reaction: A phosphoprotein + H(2)O <=> a protein + phosphate
EC number: 3.1.3.53
Name: [Myosin-light-chain] phosphatase
Reaction: [Myosin light-chain] phosphate + H(2)O <=> [myosin light-chain] + phosphate

Gene location: 2p23


Summary
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg

See this protein in other databases:
       

Literature:

Additional computationally mapped references ...


Previous
Serine/threonine-protein phosp...
Home Next
E3 ubiquitin-protein ligase RB...


Valid HTML 4.01!