Human pre-mRNA 3'-end processing machinery database

Overall statistics

* Domains assignment was taken from PFAM for all proteins including isoforms (60 proteins)

• a) RRM domain (RNA recognition motif) from PABP-1 (residues 1-190, pdb code: 4F02);
• b) WD40 domain of WDR33 which adopts a 7-bladed beta-propeller fold (residues 1-405, pdb code: 1VYH);
• c) zinc finger of CPSF4 protein (fragment 61-126, pdbcode: 2D9N).

Known domains in pre-mRNA 3'-end processing

PFAM - read more about this domain in Pfam database
(to sort click on the column header)

Name	Protein	Length	Localization	IUR %	low complexity %	secondary structure %	helix %	sheet %	PFAM
RRM_1	PABP-1	70	13-83	0.0	0.0	57.14	28.57	28.57
RRM_1	PABP-1	68	101-169	0.0	0.0	63.24	30.88	32.35
RRM_1	PABP-1	69	193-262	18.84	0.0	62.32	30.43	31.88
RRM_1	PABP-1	68	296-364	0.0	0.0	60.29	27.94	32.35
PABP	PABP-1	71	543-614	66.2	18.31	70.42	70.42	0.0
RRM_1	PABP-2	69	174-243	0.0	0.0	57.97	28.99	28.99
RRM_1	PABP-3	70	13-83	0.0	0.0	55.71	28.57	27.14
RRM_1	PABP-3	68	101-169	0.0	0.0	63.24	30.88	32.35
RRM_1	PABP-3	69	193-262	18.84	0.0	62.32	30.43	31.88
RRM_1	PABP-3	68	296-364	0.0	0.0	60.29	27.94	32.35
PABP	PABP-3	71	538-609	61.97	25.35	70.42	70.42	0.0
RRM_1	PABP-4	70	13-83	0.0	0.0	55.71	28.57	27.14
RRM_1	PABP-4	68	101-169	0.0	0.0	63.24	30.88	32.35
RRM_1	PABP-4	69	193-262	5.8	0.0	62.32	30.43	31.88
RRM_1	PABP-4	68	296-364	0.0	0.0	61.76	29.41	32.35
PABP	PABP-4	71	552-623	69.01	33.8	71.83	71.83	0.0
RRM_1	PABP-5	70	20-90	0.0	0.0	58.57	30.0	28.57
RRM_1	PABP-5	68	108-176	0.0	0.0	61.76	30.88	30.88
RRM_1	PABP-5	69	201-270	0.0	0.0	62.32	30.43	31.88
RRM_1	PABP-5	68	304-372	4.41	0.0	63.24	30.88	32.35
PAP_central	PAPOLA	348	17-365	4.02	20.4	54.02	44.25	9.77
NTP_transf_2	PAPOLA	99	76-175	0.0	31.31	53.54	24.24	29.29
PAP_RNA-bind	PAPOLA	142	366-508	21.83	0.0	52.82	29.58	23.24
PAP_central	PAPOLB	348	17-365	3.74	22.13	54.31	43.68	10.63
NTP_transf_2	PAPOLB	103	72-175	0.0	25.24	58.25	27.18	31.07
PAP_RNA-bind	PAPOLB	142	366-508	11.97	0.0	57.04	34.51	22.54
PAP_central	PAPOLG	348	16-364	2.3	0.0	53.16	43.68	9.48
NTP_transf_2	PAPOLG	103	71-174	0.0	0.0	54.37	27.18	27.18
PAP_RNA-bind	PAPOLG	142	365-507	11.27	0.0	54.23	29.58	24.65
PAP_assoc	PAPD1	48	436-484	0.0	0.0	41.67	27.08	14.58
PAP_assoc	PAPD4	54	386-440	0.0	0.0	44.44	25.93	18.52
zf-met	TUT1	24	16-40	100.0	0.0	66.67	29.17	37.5
RRM_6	TUT1	64	58-122	32.81	50.0	56.25	29.69	26.56
PAP_assoc	TUT1	59	490-549	0.0	100.0	37.29	23.73	13.56
MMS1_N	CPSF1	582	92-674	14.6	14.6	40.38	0.52	39.86
CPSF_A	CPSF1	336	1073-1409	2.68	0.0	53.87	8.93	44.94
Lactamase_B	CPSF3	219	20-239	0.0	26.03	48.86	24.2	24.66
Beta-Casp	CPSF3	121	246-367	0.0	0.0	57.85	47.11	10.74
RMMBL	CPSF3	42	380-422	0.0	0.0	69.05	28.57	40.48
Lactamase_B	CPSF2	215	13-228	0.0	0.0	52.56	28.84	23.72
Beta-Casp	CPSF2	125	243-368	0.0	0.0	60.0	46.4	13.6
RMMBL	CPSF2	42	527-569	2.38	0.0	69.05	28.57	40.48
CPSF100_C	CPSF2	171	608-779	45.61	0.0	40.94	21.05	19.88
zf-CCCH	CPSF4	25	63-88	0.0	0.0	20.0	16.0	4.0
zf-CCCH	CPSF4	25	143-168	24.0	0.0	0.0	0.0	0.0
zf-CCHC	CPSF4	17	243-260	100.0	0.0	17.65	0.0	17.65
Fip1	FIP1L1	44	153-197	0.0	47.73	38.64	36.36	2.27
RRM_1	CSTF2	70	18-88	0.0	0.0	58.57	30.0	28.57
CSTF2_hinge	CSTF2	84	109-193	52.38	0.0	65.48	65.48	0.0
CSTF_C	CSTF2	45	531-576	100.0	57.78	71.11	71.11	0.0
RRM_1	CSTF2T	70	18-88	0.0	0.0	57.14	30.0	27.14
CSTF2_hinge	CSTF2T	84	109-193	42.86	0.0	63.1	63.1	0.0
CSTF_C	CSTF2T	46	570-616	100.0	76.09	71.74	71.74	0.0
Suf	CSTF3	274	375-649	22.99	43.43	57.66	57.66	0.0
WD40	CSTF1	35	101-136	0.0	0.0	57.14	0.0	57.14
WD40	CSTF1	37	164-201	0.0	0.0	56.76	0.0	56.76
WD40	CSTF1	32	258-290	0.0	0.0	53.13	0.0	53.13
WD40	CSTF1	38	296-334	0.0	0.0	50.0	0.0	50.0
WD40	CSTF1	33	392-425	0.0	0.0	51.52	0.0	51.52
RRM_6	CPSF6	70	83-153	0.0	0.0	51.43	28.57	22.86
RRM_1	CPSF7	72	84-156	0.0	0.0	51.39	27.78	23.61
NUDIX_2	CPSF5	187	35-222	2.67	0.0	52.41	21.39	31.02
CTD_bind	PCF11	57	70-127	0.0	1.75	78.95	78.95	0.0
MobB	CLP1	115	115-230	0.0	0.0	53.04	30.43	22.61
Clp1	CLP1	192	232-424	0.52	0.0	48.96	19.79	29.17
DUF3453	Symplekin	237	117-354	15.61	13.5	64.98	63.71	1.27
Symplekin_C	Symplekin	182	887-1069	2.2	0.0	68.68	65.93	2.75
WD40	WDR33	38	151-189	0.0	0.0	50.0	10.53	39.47
WD40	WDR33	38	192-230	0.0	0.0	55.26	15.79	39.47
WD40	WDR33	33	234-267	0.0	0.0	42.42	0.0	42.42
WD40	WDR33	38	278-316	0.0	0.0	55.26	0.0	55.26
WD40	WDR33	39	321-360	0.0	0.0	53.85	10.26	43.59
WD40	WDR33	32	371-403	0.0	0.0	34.38	0.0	34.38
Collagen	WDR33	65	662-727	100.0	100.0	0.0	0.0	0.0
Collagen	WDR33	61	715-776	100.0	100.0	0.0	0.0	0.0
Metallophos	PP-1A	195	57-252	0.0	0.0	51.28	38.46	12.82
Metallophos	PP-1B	195	56-251	0.0	0.0	51.79	38.97	12.82
DWNN	RBBP6	72	4-76	2.78	16.67	44.44	15.28	29.17
zf-CCHC	RBBP6	16	160-176	31.25	0.0	0.0	0.0	0.0
zf-C3HC4_2	RBBP6	46	255-301	0.0	0.0	21.74	19.57	2.17
WD40	WDR82	37	12-49	0.0	0.0	59.46	0.0	59.46
WD40	WDR82	38	97-135	0.0	0.0	55.26	0.0	55.26
WD40	WDR82	22	245-267	0.0	0.0	59.09	0.0	59.09
WD40	WDR82	31	273-304	0.0	0.0	45.16	0.0	45.16
Ssu72	SSU72	190	4-194	0.0	0.0	60.53	43.68	16.84
RNA_pol_Rpb1_1	RPB1	339	15-354	20.65	0.0	42.48	35.1	7.37
RNA_pol_Rpb1_2	RPB1	165	356-521	0.0	0.0	35.15	18.18	16.97
RNA_pol_Rpb1_3	RPB1	168	524-692	0.0	0.0	48.81	30.95	17.86
RNA_pol_Rpb1_4	RPB1	107	716-823	8.41	0.0	47.66	45.79	1.87
RNA_pol_Rpb1_5	RPB1	598	830-1428	2.34	0.0	56.52	43.65	12.88
RNA_pol_Rpb1_6	RPB1	183	896-1079	0.0	0.0	66.67	64.48	2.19
RNA_pol_Rpb1_7	RPB1	135	1164-1299	10.37	0.0	56.3	32.59	23.7