Home
Disorder
Domains
Protein interactions
Sub-complexes    CPSF
   CstF
   CFIm
   CFIIm
Other proteins    PABP-1
   PAPOLA
   RPB1
   PP-1A
   PP-1B
   Symplekin
   WDR82
   SSU72
   RBBP6
Download
FAQ

Poly(A) polymerase beta


Known also as: Polynucleotide adenylyltransferase beta, Testis-specific poly(A) polymerase
Known abbreviations: PAPOLB, PAPT, TPAP

Yeast homolog: not known

Protein




Models
Domains

Secondary structure

Disorder

Top 3 models:
Template: 3c66, chain A
Method: compass
Fragment: 1-497
Template: 2q66, chain A
Method: csblast
Fragment: 17-436
Template: 3dxj, chain N
Method: compass
Fragment: 371-630


Sequence length:636 aa
Molecular weight:71.681 kDa
Isoelectric point:6.18

Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQRRILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPSHVDRSDFF
TSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLY
PNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWSKLFEAPSFFQKYKHYIVLLASASTEKQHLEW
VGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEMGMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLND
SSFDLSAGCENSMSVPSSTSTMKTGPLISSSQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAVSQPAISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL


Enzyme
EC number: 2.7.7.19
Name: Polynucleotide adenylyltransferase
Reaction: ATP + RNA(n) <=> diphosphate + RNA(n+1)

Gene location: 7p22.1


Summary
The protein belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Interacts with GSG1

Testis specific.

See this protein in other databases:
         

Literature:

Additional computationally mapped references ...


Previous
Poly(A) polymerase alpha
         
Home Next
Poly(A) polymerase gamma
         


Valid HTML 4.01!