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Disorder
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Protein interactions
Sub-complexes    CPSF
   CstF
   CFIm
   CFIIm
Other proteins    PABP-1
   PAP
   RPB1
   PP-1A
   PP-1B
   Symplekin
   WDR82
   SSU72
   RBBP6
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FAQ

Human pre-mRNA 3'-end processing machinery database


Sequences of human proteins were taken from UniProt.

Molecular weights and theoretical isoelectric points were calculated by Isoelectric Point Calculator.

Protein disorder was predicted using GeneSilico MetaDisorder.

Secondary structure is taken from GeneSilico Fold Recognition metaserver. It is arithmetic consensus based on predictions of psipred, prof, jnet, sable, proteus, sspro4, psspred, spineX, raptorxss, SPARROW, *SPARROW, HMMSTR, porter, spine, nnssp, pssfinder, sspal, ssp, sspred, netsurfp, soprano. For more details simply see secondary structure raw output. Three letter alphabet is used: H - for α helix, E - for β sheet and '-' for others.

Low complexity were calculated by SEG.

Domains are taken from PFAM.

Domains boundaries are predicted by DomainSVM.

Models:
Templates are based on predictions from GeneSilico Fold Recognition metaserver. It allows to automatic search for remote homology by using PSI-BLAST, COMA, PRC, COMPASS, CSBLAST, HHSEARCH, HHBLITS, FFAS, MGenThreader, Phyre, Sp3 and PCONS.
Next, based on alignments to known structures from PDB two kind of models are build. Crude models are simple models based on coordinates taken from template. More advanced models are build by MODELLER program.

Predictions, models and other type of data are available as flat files in download section.


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Contact: Lukasz Kozlowski

This work was supported by Polish Ministry of Science and Higher Education (grant NN301 190139).

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