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Serine/threonine-protein phosphatase PP1-alpha catalytic subunit


Known abbreviations: PP-1A, PP1A, PP1alpha, PPP1A, PPP1CA

Yeast homolog: GLC7

Protein




Structures



Models
Domains

Secondary structure

Disorder

Top 3 models:
Template: 1fjm, chain A
Method: hhsearch
Fragment: 1-330
Template: 3e7a, chain A
Method: hhsearch
Fragment: 1-300
Template: 1s70, chain A
Method: phyre
Fragment: 1-205


This protein has alternative isoforms:
Isoform 1:
Sequence length:330 aa
Molecular weight:37.512 kDa
Isoelectric point:6.05
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
NRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAK
RQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK



Isoform 2:
Sequence length:341 aa
Molecular weight:38.631 kDa
Isoelectric point:6.35
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSDSEKLNLDSIIGRLLEGSRVLTPHCAPVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFF
LLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQ
VVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK



Enzyme
EC number: 3.1.3.16
Name: Phosphoprotein phosphatase
Reaction: A phosphoprotein + H(2)O <=> a protein + phosphate

Gene location: 11q13


Summary
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory.

Interacts with PPP1R39

See this protein in other databases:
       

Literature:

Additional computationally mapped references ...


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