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WD repeat-containing protein 82


Known abbreviations: WDR82, MST107, MSTP107, PRO2730, PRO34047, Swd2, TMEM113, UNQ9342_PRO34047, WDR82A

Yeast homolog: not known

Protein




Models
Domains

Secondary structure

Disorder

Top 3 models:
Template: 1nr0, chain A
Method: hhsearch
Fragment: 1-313
Template: 2g9a, chain A
Method: phyre
Fragment: 8-312
Template: 2ovr, chain B
Method: mgenthreader
Fragment: 1-313


Sequence length:313 aa
Molecular weight:35.079 kDa
Isoelectric point:7.56

Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKT
IRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSED
GKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD


Gene location: 3p21.2


Summary
WDR82 is regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex.

Interacts with CUL4B. Interacts with RBBP5 and SETD1B.
Interacts with SETD1A (via RRM domain), POLR2B.
Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS.
Interacts with PPP1CA in the presence of PPP1R10/PNUTS.

See this protein in other databases:
       

Literature:

Additional computationally mapped references ...


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