Home
Disorder
Domains
Protein interactions
Sub-complexes    CPSF
   CstF
   CFIm
   CFIIm
Other proteins    PABP-1
   PAPOLA
   RPB1
   PP-1A
   PP-1B
   Symplekin
   WDR82
   SSU72
   RBBP6
Download
FAQ

Cleavage stimulation factor subunit 2 tau variant


Known also as: CF-1 64 kDa subunit tau variant, Cleavage stimulation factor 64 kDa subunit tau variant
Known abbreviations: CSTF2T, CstF-64T, KIAA0689, TauCstF-64

Yeast homolog: SPAC644.16

Protein




Models
Domains

Secondary structure

Disorder

This protein is highly disordered (79 % of residues are predicted to be disordered)

Top 3 models:
Template: 2qfj, chain A
Method: hhsearch
Fragment: 1-204
Template: 3dxj, chain N
Method: compass
Fragment: 18-461
Template: 2qfj, chain A
Method: phyre
Fragment: 1-204


Sequence length:616 aa
Molecular weight:64.436 kDa
Isoelectric point:7.0

Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITR
AVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQG
GIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPLERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHASGHDTRGPSSHEMRGGPLGDPRL
LIGEPRGPMIDQRGLPMDGRGGRDSRAMETRAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQG
AGIQGGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS


Gene location: 10q11


Summary
CSTF2T may play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs

Phosphorylated upon DNA damage, probably by ATM or ATR.

See this protein in other databases:
       

Literature:

Additional computationally mapped references ...


Previous
Cleavage stimulation factor su...
Home Next
Cleavage stimulation factor su...


Valid HTML 4.01!