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Cleavage stimulation factor subunit 2 tau variant
Known also as: CF-1 64 kDa subunit tau variant, Cleavage stimulation factor 64 kDa subunit tau variant
Known abbreviations: CSTF2T, CstF-64T, KIAA0689, TauCstF-64
Yeast homolog: SPAC644.16
Protein
Models Domains Secondary structure Disorder |
This protein is highly disordered (79 % of residues are predicted to be disordered)
Top 3 models:
 |  |  |
| Template: 2qfj, chain A Method: hhsearch Fragment: 1-204 | Template: 3dxj, chain N Method: compass Fragment: 18-461 | Template: 2qfj, chain A Method: phyre Fragment: 1-204 |
| Sequence length: | 616 aa |
| Molecular weight: | 64.436 kDa |
| Isoelectric point: | 7.0 |
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITR
AVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQG
GIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPLERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHASGHDTRGPSSHEMRGGPLGDPRL
LIGEPRGPMIDQRGLPMDGRGGRDSRAMETRAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQG
AGIQGGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS
Gene location: 10q11
Summary
CSTF2T may play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs
Phosphorylated upon DNA damage, probably by ATM or ATR.
See this protein in other databases:
Literature:
- Dass B, McMahon KW, Jenkins NA et al. The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. J Biol Chem 2001 276(11):8044-50, doi: 10.1074/jbc.M009091200, PMID: 11113135.
- Dass B, McDaniel L, Schultz RA et al. The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein tauCstF-64, lacks introns and may be associated with male sterility. Genomics 2002 80(5):509-14, doi: , PMID: 12408968.
- Huber Z, Monarez RR, Dass B et al. The mRNA encoding tauCstF-64 is expressed ubiquitously in mouse tissues. Ann N Y Acad Sci 2005 1061:163-72, doi: 10.1196/annals.1336.017, PMID: 16467265.
- Dass B, Tardif S, Park JY et al. Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility. Proc Natl Acad Sci U S A 2007 104(51):20374-9, doi: 10.1073/pnas.0707589104, PMID: 18077340.
- Hockert KJ, Martincic K, Mendis-Handagama SM et al. Spermatogenetic but not immunological defects in mice lacking the tauCstF-64 polyadenylation protein. J Reprod Immunol 2011 89(1):26-37, doi: 10.1016/j.jri.2011.01.018, PMID: 21489638.
- Li W, Yeh HJ, Shankarling GS et al. The tauCstF-64 polyadenylation protein controls genome expression in testis. PLoS One 2012 7(10):e48373, doi: 10.1371/journal.pone.0048373, PMID: 23110235.
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