Home
Disorder
Domains
Protein interactions
Sub-complexes    CPSF
   CstF
   CFIm
   CFIIm
Other proteins    PABP-1
   PAPOLA
   RPB1
   PP-1A
   PP-1B
   Symplekin
   WDR82
   SSU72
   RBBP6
Download
FAQ

Poly(A) RNA polymerase GLD2


Known also as: PAP-associated domain-containing protein 4, Terminal uridylyltransferase
Known abbreviations: PAPD4, GLD2

Yeast homolog: not known

Protein

1
484



Models
Domains

Secondary structure

Disorder

Top 3 models:
Template: 2ikf, chain A
Method: hhsearch
Fragment: 116-476
Template: 2q0d, chain B
Method: phyre
Fragment: 132-164
Template: 2b4v, chain A
Method: prc
Fragment: 303-473


This protein has alternative isoforms:
Isoform 1:
Sequence length:484 aa
Molecular weight:56.028 kDa
Isoelectric point:9.65
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIV
RCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLI
RAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDL
LLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR



Isoform 2:
Sequence length:480 aa
Molecular weight:55.502 kDa
Isoelectric point:9.72
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIV
RCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKV
PIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGF
LKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR



Enzyme
EC number: 2.7.7.19
Name: Polynucleotide adenylyltransferase
Reaction: ATP + RNA(n) <=> diphosphate + RNA(n+1)

Gene location: 5q14.1


Summary
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation.

Interacts with CPEB1, CPEB2, CPSF1 and PABPC1

Expressed in brain (cerebellum, hippocampus and medulla).

See this protein in other databases:
         

Literature:

Additional computationally mapped references ...


Previous
Mitochondrial poly(A) RNA poly...
Home Next
Speckle targeted PIP5K1A-regul...


Valid HTML 4.01!