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Cleavage and polyadenylation specificity factor subunit 7


Known also as: Cleavage and polyadenylation specificity factor 59 kDa subunit
Known abbreviations: CPSF7, CFIm59

Yeast homolog: not known

Protein




Structures Models
Domains

Secondary structure

Disorder

This protein is highly disordered (79 % of residues are predicted to be disordered)

Top 3 models:
Template: 3q2s, chain C
Method: hhsearch
Fragment: 4-278
Template: 3n9u, chain C
Method: mgenthreader
Fragment: 82-177
Template: 3dxj, chain N
Method: compass
Fragment: 9-396


This protein has alternative isoforms:
Isoform 1:
Sequence length:471 aa
Molecular weight:52.05 kDa
Isoelectric point:7.95
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEV
VVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPG
IHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCR
VLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH



Isoform 2:
Sequence length:462 aa
Molecular weight:51.096 kDa
Isoelectric point:7.66
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEV
VVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPP
PPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDC
LHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH



Isoform 3:
Sequence length:514 aa
Molecular weight:56.375 kDa
Isoelectric point:9.05
Sequence:
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MGRPESAGGGSRGPFEGGGRARRAGGIFLTLSILRTRDLPSGAMSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVG
SFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDK
PPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAI
SSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH



Gene location: 11q12.2


Summary
CPSF7 is a component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. It has a domain organization reminiscent of spliceosomal proteins. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7).

Interacts with NUDT21/CPSF5.

See this protein in other databases:
       

Literature:

Additional computationally mapped references ...


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