 |
||||||||
|
||||||||
 |
||||||||
Cleavage and polyadenylation specificity factor subunit 7
Known also as: Cleavage and polyadenylation specificity factor 59 kDa subunit
Known abbreviations: CPSF7, CFIm59
Yeast homolog: not known
Protein
Structures Models Domains Secondary structure Disorder |
This protein is highly disordered (79 % of residues are predicted to be disordered)
Top 3 models:
 |  |  |
| Template: 3q2s, chain C Method: hhsearch Fragment: 4-278 | Template: 3n9u, chain C Method: mgenthreader Fragment: 82-177 | Template: 3dxj, chain N Method: compass Fragment: 9-396 |
This protein has alternative isoforms:
Isoform 1:
| Sequence length: | 471 aa |
| Molecular weight: | 52.05 kDa |
| Isoelectric point: | 7.95 |
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEV
VVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPG
IHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCR
VLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
Isoform 2:
| Sequence length: | 462 aa |
| Molecular weight: | 51.096 kDa |
| Isoelectric point: | 7.66 |
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEV
VVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPP
PPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDC
LHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
Isoform 3:
| Sequence length: | 514 aa |
| Molecular weight: | 56.375 kDa |
| Isoelectric point: | 9.05 |
1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130
MGRPESAGGGSRGPFEGGGRARRAGGIFLTLSILRTRDLPSGAMSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVG
SFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDK
PPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAI
SSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
Gene location: 11q12.2
Summary
CPSF7 is a component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. It has a domain organization reminiscent of spliceosomal proteins. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7).
Interacts with NUDT21/CPSF5.
See this protein in other databases:
Literature:
- Brown KM, Gilmartin GM. A mechanism for the regulation of pre-mRNA 3" processing by human cleavage factor Im. Mol Cell 2003 12(6):1467-76, doi: , PMID: 14690600.
- Sartini BL, Wang H, Wang W et al. Pre-messenger RNA cleavage factor I (CFIm): potential role in alternative polyadenylation during spermatogenesis. Biol Reprod 2008 78(3):472-82, doi: 10.1095/biolreprod.107.064774, PMID: 18032416.
- Kim S, Yamamoto J, Chen Y et al. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells 2010 15(9):1003-13, doi: 10.1111/j.1365-2443.2010.01436.x, PMID: 20695905.
- Ruegsegger U, Beyer K, Keller W et al. Purification and characterization of human cleavage factor Im involved in the 3" end processing of messenger RNA precursors. J Biol Chem 1996 271(11):6107-13, doi: , PMID: 8626397.
| Previous Cleavage and polyadenylation s... |
Home | Next Cleavage and polyadenylation s... |
|
|
